Awarded Grants

Awarded a one-year, $100,000 grant from Pachyonychia Congenita Project. Project Title: Keratin 16 provides a new paradigm for keratin function in palmoplantar skinPrincipal Investigator (PI) Name: Pierre A. Coulombe, PhDPI Affiliations: University of Michigan Medical School … [Read more...] about Pierre Coulombe: 2025 PC Grant Award Recipient

Awarded a one-year, $19,950 grant from Pachyonychia Congenita Project. Pachyonychia congenita and palmoplantar disorders are rare, painful, and inherited skin and nail disorders. We intend to employ advanced genetic testing methods on several affected families from diverse Pakistani ethnicities … [Read more...] about Sajid Malik: 2025 PC Grant Award Recipient

Awarded a one-year, $100,000 grant from Pachyonychia Congenita Project. To thoroughly understand pachyonychia congenita, this disease ought to be studied in models. A mouse models was recently generated. It offers the opportunity to investigate pachyonychia congenita at the cell and molecular … [Read more...] about Jiang Chen: 2025 PC Grant Award Recipient

Awarded a two-year, $145,447 grant from Pachyonychia Congenita Project. Pachyonychia congenita (PC) is a rare genetic skin condition that causes thick, painful skin on the hands and feet, making walking and daily activities difficult. This project aims to closely study PC skin at a very detailed … [Read more...] about Alain Hovnanian: 2025 PC Grant Award Recipient

Awarded a one-year, $100,000 grant from Pachyonychia Congenita Project. Of all of the features of Pachyonychia Congenita, pain in the hands and feet arguably has the most negative impact on quality of life, and is frustratingly difficult to treat. We propose to use genetically engineered mice … [Read more...] about Michael Caterina: 2024 PC Grant Award Recipient

Awarded a one-year, $99,206 grant from Pachyonychia Congenita Project. All potential therapies for PC (Pachyonychia Congenita), from traditional drug molecules to advanced gene-editing approaches, must eventually confront a common challenge: delivery of the therapeutic agents into the upper layer … [Read more...] about Joshua Tam: 2024 PC Grant Award Recipient

Awarded a one-year, $50,000 grant from Pachyonychia Congenita Project. Pachyonychia congenita (PC) is one of several inherited skin diseases caused by mutations in keratin genes, which are responsible for forming a scaffold within skin cells that gives the skin strength. PC patients develop … [Read more...] about Benjamin Nanes: 2024 PC Grant Award Recipient

Awarded a one-year, $99,960 grant from Pachyonychia Congenita Project. Pachyonychia congenita (PC) is a genetic disease primarily characterized by abnormal nails as well as thickening of the skin of the palms, resulting in painful plantar skin that greatly impacts patients' quality of life. There … [Read more...] about Eli Sprecher: 2024 PC Grant Award Recipient