Also known as tyrosinaemia type II (Richner-Hanhart syndrome) TAT-pEDD is a rare genetic skin condition that causes erosive keratoderma on the soles and, unusually, follows the finger dermatoglyphics (epidermal ridges that constitute … [Read more...] about TAT-pEDD (palmoplantar Epidermal Differentiation Disorder)
Pachyonychia Congenita Conditions
SLURP1-pEDD
Also known as Mal de Meleda SLURP1-pEDD is a rare genetic skin condition that causes palmoplantar keratoderma (PPK) and, in some patients, progressive symmetric erythrokeratoderma (PSEK). Affected skin can appear whitish and diffusely thickened on the palms and soles, sometimes … [Read more...] about SLURP1-pEDD
PERP-pEDD (palmoplantar Epidermal Differentiation Disorder)
Also known as Olmsted syndrome PERP-pEDD is a rare genetic skin condition that causes extremely painful, thickened skin on the palms and soles, along with scaly patches around the mouth, nose, and eyes and in skin folds such as the armpits, breast, and groin.1 It is caused by … [Read more...] about PERP-pEDD (palmoplantar Epidermal Differentiation Disorder)
Ears
Some patients especially PC-K6a children experience short sharp ear pain. Additional study is needed to learn more and find correlations between pain in ears and PC. CARING FOR EARS FIRST BITE SYNDROME "First Bite Syndrome" is the only term we have found that comes close to describing … [Read more...] about Ears
Neurovascular Structures
Painful blood vessels or nerve endings grow in calluses and make trimming difficult and increasing the pain. The neurovascular structures (NVS) can be seen or unseen and if get hit causing shooting pain and bleeding. CARING FOR NVS Dr. Edel O'Toole, MD, PhD, "NVS..." In 2019, PC Project … [Read more...] about Neurovascular Structures
Itch
Deep itch happens under, around, or in the calluses and sometimes cysts. Like the painful calluses, this deep itching can interfere with sleep and make the feet feel uncomfortable and irritable. Trying to itch the deep itch can cause the skin to blister and creates additional pain. CARING FOR … [Read more...] about Itch
Cracks
Cracks in the skin on hands or feet are annoying and cause additional pain. Cracks happen across all mutations and catch on clothing or bedding. CARING FOR CRACKS Dr. C. David Hansen, MD, "Cracks in the outside layer of the skin are usually called fissures. These occur with thickening of the … [Read more...] about Cracks
Pain
The veritable constant pain is the worst thing about PC. PC causes a unique type of chronic pain unlike that of most other syndromes. Further, PC pain is a very individual matter and varies greatly from day to day, season to season. As one patient said “I would say the worst thing for me … [Read more...] about Pain
